Use of Plasmoquine in Subtertian Malaria

?tv, *s Sreat value to every medical practitioner. The note is divided into two sections: I. The effect of plasmoquine on the viability of crescents. II. The effect of plasmoquine on the development ?f crescents. In the first section the literature of the subject is reviewed and special attention is called to the suggestions of Miihlens and Cordes that mass treatment with plasmoquine may be effective as a means of malaria control on a large scale. The more recent findings of Barber, Komp and ??hitmore suggest that very small doses of plasmoquine, ?ven single doses of 5 milligrammes, may sterilize the Wood of infected persons in such a way that mosquitoes Av'ill be unable to become infected by feeding on them. Carefully conducted experiments by Russell Amies afford strong prima facie evidence that two doses of V3 grain of plasmoquine, given with an interval of 16 hours between, rendered all the crescents of a carrier non-viable, and also that the crescents remained ^on-viable for at least three days. He also found that Plasmoquine when given every fourth day in doses of ~/3 grain produced the same effects with regard to ^osquito infection as the administration of the same dose every day. The number of cases studied was too small to justify a dogmatic generalization, but at any rate the results obtained are of remarkable interest. If it should be established that small safe doses of plasmoquine will render the patient non-infective to mosquitoes the whole problem of malaria control may enter on a new phase. t)r. Russell Amies suggests that the treatment of subtertian malaria based on his findings should consist of -0 grains of quinine hydrochloride daily and 2/3 grain of plasmoquine every fourth day. The minimum period of treatment should be ten days but it is preferable to continue treatment for 30 days. He considers that larger doses of quinine, such as 30 grains and over are unnecessary, but in the treatment of pernicious' types the question of dosage must be left to the experience of the physician. He also recommends the use of alkalies as advocated by Sinton. In the second section of the bulletin he deals with the effect of plasmoquine on the development of crescents and incidentally with the influence of quinine